Odevixibat
Odevixibat is a reversible IBAT inhibitor for treating cholestatic liver diseases with severe pruritus by blocking bile acid reabsorption.
Odevixibat is a bile acid transporter inhibitor used to reduce severe itching in patients with certain genetic cholestatic liver diseases.
Key facts at a glance
- ATC
- A05AX05
- RxNorm
- 2563966
- Generic
- Odevixibat
- Class
- atc-a05
- Brands
- Bylvay
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Odevixibat is indicated for the treatment of pruritus (itching) associated with Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS), genetic disorders that impair bile flow from the liver.
Odevixibat is a reversible inhibitor of the ileal bile acid transporter (IBAT). It blocks the reabsorption of bile acid salts in the terminal ileum, reducing the accumulation of bile acids in the liver and circulation, which helps alleviate associated symptoms like pruritus.
As an IBAT inhibitor, odevixibat may cause gastrointestinal effects such as diarrhea. Liver function monitoring may be required during treatment. It is typically used in patients with confirmed genetic cholestatic disease. Safety and efficacy in children is established for specific subtypes of PFIC and ALGS.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy