Ohtuvayre
Ohtuvayre (ensifentrine) is a prescription inhaled medication used as maintenance treatment for chronic obstructive pulmonary disease (COPD) in adults. It is delivered via nebulizer and works as a dual phosphodiesterase 3 and 4 inhibitor, helping to reduce airway inflammation and improve breathing. This was the first COPD inhaler approved in decades that does not contain a corticosteroid.
Ohtuvayre is a nebulized COPD maintenance therapy that uses a novel dual PDE3/PDE4 inhibitor mechanism to improve breathing and reduce exacerbations in adults.
Key facts at a glance
- RxNorm
- 2687222
- Generic
- Ohtuvayre
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ohtuvayre is indicated for the maintenance treatment of COPD in adults. It is not intended for acute bronchospasm relief and should not replace rescue inhalers.
Ohtuvayre contains ensifentrine, a dual phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) inhibitor. By inhibiting these enzymes, it increases intracellular cyclic AMP levels, which helps reduce inflammation, relax airway smooth muscle, and improve lung function.
Ohtuvayre is administered twice daily via nebulizer. Common side effects may include back pain, diarrhea, and urinary tract infections. Patients should inform their healthcare provider of all medications and medical conditions before starting treatment. Effectiveness and safety in pediatric patients have not been established.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy