Olezarsen
Olezarsen is an antisense oligonucleotide (ASO) therapy designed to lower triglyceride levels by specifically targeting and degrading apoC-III messenger RNA. By reducing apoC-III protein levels, it increases the clearance of triglycerides and very low-density lipoprotein (VLDL) from circulation. This medication is used for treating patients with severe hypertriglyceridemia, including those with familial chylomicronemia syndrome or other lipid disorders.
Olezarsen is an ASO therapy that reduces triglycerides by depleting apoC-III protein through targeted mRNA degradation.
Key facts at a glance
- RxNorm
- 2701418
- Generic
- Olezarsen
- Class
- unclassified
- Brands
- Tryngolza
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Olezarsen is indicated for the treatment of hypertriglyceridemia, particularly severe cases. It may be used in patients with familial chylomicronemia syndrome (FCS) or other conditions associated with severely elevated triglyceride levels.
Olezarsen is an ASO-GalNAc3 conjugate that specifically binds to apoC-III mRNA, leading to its degradation. This reduces serum apoC-III protein levels, which in turn increases the clearance of plasma triglycerides and VLDL particles from the bloodstream.
As a subcutaneous injection, Olezarsen requires regular administration. Patients should undergo routine lipid panel monitoring during treatment. Common side effects may include injection site reactions. Lifestyle modifications including diet and exercise should continue alongside therapy. Consultation with a healthcare provider is essential for proper patient selection and monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy