Oliceridine
Oliceridine is a full opioid agonist that selectively targets the mu-opioid receptor to provide potent pain relief for acute pain severe enough to require an opioid analgesic. Unlike partial agonists, it has no ceiling effect, meaning that higher doses can provide greater analgesia within safe limits. This medication is administered intravenously in clinical settings.
Oliceridine is an IV opioid analgesic for acute pain that works as a full mu-opioid receptor agonist with no ceiling effect.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N02AX07
- RxNorm
- 2392230
- Generic
- Oliceridine
- Class
- atc-n02
- Brands
- Olinvyk
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 0.35-0.5mg bolus
- Maximum
- consult physician
- Frequency
- every 6 minutes as needed (PCA)
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.015mg/kg bolus
- Maximum
- consult physician
- Frequency
- every 6 minutes as needed (PCA)
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.25mg bolus
- Maximum
- consult physician
- Frequency
- every 6 minutes as needed (PCA)
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteruse lowest effective dose
avoid use during first trimester unless benefits significantly outweigh risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective dose
use only if benefits outweigh risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid if possible
avoid use near term due to risk of respiratory depression in newborn
close fetal and neonatal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid
discontinue breastfeeding or avoid use; unknown if excreted in human milk
monitor infant for sedation or respiratory depression
geriatric
elderlyreduce dose by 25-50%
start at lowest dose, monitor closely for respiratory depression and sedation
frequent vital sign monitoring
Use with caution and monitor for adverse effects.
pediatric_age
under 18 yearsnot recommended
safety and efficacy not established in patients under 18 years
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
severereduce dose by 50%
use with caution; monitor for accumulation and respiratory depression
close monitoring of renal function and drug levels
Use with caution and monitor for adverse effects.
hepatic_impairment
moderatereduce dose by 50%
use with caution; monitor for increased sedation and respiratory depression
monitor liver function and drug response
Use with caution and monitor for adverse effects.
Statistics and clinical data
FDA approval year
FDA approval for acute pain management
Drug class
Pharmacological classification
Common uses
Therapeutic indication
Route of administration
Delivery method
Management of acute pain severe enough to require an opioid analgesic in adult patients, typically in hospital or clinical settings.
Oliceridine is a full agonist at the mu-opioid receptor. By binding to these receptors in the brain and spinal cord, it activates pain-inhibiting pathways and reduces the perception of pain signals. As a full agonist, it provides maximum analgesic effect without the ceiling limitation seen with partial agonists.
Administered via intravenous route only. Like all opioids, it carries risks of dependence, respiratory depression, and other opioid-related adverse effects. Dosage should be individually titrated based on patient response and pain severity.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy