Olopatadine
Olopatadine is a selective histamine H1 receptor antagonist used primarily as a nasal spray to treat allergic rhinitis symptoms such as sneezing, nasal itching, runny nose, and nasal congestion. It is available in both prescription and over-the-counter formulations, with options for adults and children as young as 6 years old.
Olopatadine is an antihistamine nasal spray that relieves allergy symptoms like sneezing, itching, and runny nose by blocking histamine action.
Key facts at a glance
- ATC
- R01AC09
- RxNorm
- unknown
- Generic
- Olopatadine
- Class
- atc-r01
- Brands
- Ryaltris, Pataday, PATANASE
- Availability
- otc
- Pregnancy
- C
- Lactation
- unknown
- Half-life (h)
- 3
- Onset (min)
- 30
- Duration (h)
- 8
- Routes
- nasal, ophthalmic
- Forms
- nasal spray, eye drops
- Regions
- United States, Canada, European Union, United Kingdom, Australia
- Monitoring
- allergic reactions, local irritation
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Olopatadine nasal spray is indicated for the treatment of seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis in adults and children 6 years and older. The ophthalmic formulation is used for allergic conjunctivitis (itchy, watery eyes).
Olopatadine works by selectively blocking histamine H1 receptors, preventing histamine from binding and triggering allergic inflammatory responses. This reduces symptoms like sneezing, itching, rhinorrhea, and nasal congestion associated with allergic reactions.
Common side effects include bitter taste, headache, and nasal discomfort. The spray should be primed before first use and not shared with others. Patients with glaucoma or urinary retention should use caution. Alcohol may increase drowsiness when using this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy