Olsalazine
Olsalazine is an intestinal anti-inflammatory medication used primarily for the treatment and maintenance of remission in ulcerative colitis. It is a prodrug that releases 5-aminosalicylic acid (5-ASA).
Olsalazine is a colon-specific 5-ASA prodrug used to induce and maintain remission in ulcerative colitis.
Key facts at a glance
- ATC
- A07EC03
- RxNorm
- 32385
- Generic
- Olsalazine
- Class
- atc-a07
- Brands
- Dipentum
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of active mild to moderate ulcerative colitis and maintenance of remission in patients with chronic ulcerative colitis.
Olsalazine is a prodrug that remains inactive until it reaches the colon, where resident bacteria cleave the azo bond to release 5-aminosalicylic acid (5-ASA/mesalazine). The 5-ASA then exerts a topical anti-inflammatory effect directly on colonic epithelial cells, reducing inflammation in the intestinal mucosa.
Diarrhea is a common side effect (occurring in approximately 10-20% of patients). Should be used with caution in patients with renal impairment and avoided in patients with known hypersensitivity to salicylates. May also cause photosensitivity reactions. Regular monitoring of renal function may be recommended during prolonged therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy