Ongentys
Ongentys (opicapone) is a prescription brand-name medication used as an adjunct treatment to levodopa/carbidopa therapy in patients with Parkinson's disease. It belongs to a class of drugs called COMT inhibitors and helps reduce 'off' episodes by extending the effects of levodopa.
Ongentys is a Parkinson's disease medication that helps extend the effectiveness of levodopa therapy and reduce motor fluctuations.
Key facts at a glance
- RxNorm
- 2362173
- Generic
- Ongentys
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ongentys is indicated for the treatment of Parkinson's disease in patients experiencing end-of-dose 'off' episodes despite optimized levodopa/carbidopa therapy. It is used as an adjunct treatment to reduce OFF time.
Ongentys contains opicapone, a catechol-O-methyltransferase (COMT) inhibitor. It works by inhibiting the COMT enzyme that breaks down levodopa in the peripheral body, thereby prolonging levodopa's duration of action and increasing its availability to the brain.
Ongentys is taken once daily at bedtime, at least one hour before or after levodopa combinations. Common side effects may include dyskinesia, dizziness, and constipation. Patients should inform their doctor about all medications and health conditions before starting treatment, as it may interact with other drugs.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy