Onzetra
Onzetra is a prescription nasal powder medication used to treat acute migraine headaches with or without aura in adults. It delivers the active ingredient sumatriptan directly through the nasal passage using a breath-powered delivery device, providing an alternative to oral or injectable migraine medications.
Onzetra is a prescription nasal powder medication for the acute treatment of migraine attacks in adults.
Key facts at a glance
- RxNorm
- 1739333
- Generic
- Onzetra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Onzetra is indicated for the acute treatment of migraine headaches with or without aura in adults. It is not used for migraine prevention and should not be used to treat cluster headaches or other types of headaches.
Onzetra contains sumatriptan, a serotonin 5-HT1B/1D receptor agonist. As a triptan medication, it works by binding to specific serotonin receptors in the brain and blood vessels, causing vasoconstriction of cranial blood vessels and reducing inflammation and pain signals associated with migraine attacks.
Onzetra should not be used by patients with cardiovascular disease, uncontrolled hypertension, or those who have taken ergotamine or other triptans within 24 hours. Common side effects may include changes in taste, nasal discomfort, and dizziness. Patients should seek emergency medical attention if they experience chest pain, tightness, or signs of a stroke after taking this medication.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy