Opium
Belladonna/opium rectal suppository is a combination medication containing narcotic analgesic (opium/morphine) and antispasmodic (belladonna alkaloids atropine and scopolamine) components. It is primarily used for pain relief and to reduce intestinal spasms.
A combination antispasmodic and narcotic analgesic rectal suppository used to relieve severe abdominal pain and cramping.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- A07DA02
- RxNorm
- 7676
- Generic
- Opium
- Class
- atc-a07
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- rectal, oral
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
third trimesteravoid
avoid use near term due to risk of neonatal abstinence syndrome
fetal monitoring and assessment for neonatal withdrawal
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid
avoid breastfeeding during opium use
monitor infant for sedation and respiratory depression
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlyreduce dose by 25-50%
use lower doses and monitor closely for adverse effects
monitor for sedation, respiratory depression, constipation, and falls
Use with caution and monitor for adverse effects.
pediatric_age
children under 12avoid use
contraindicated in children due to high risk of respiratory depression
close monitoring if accidentally exposed
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
moderate to severereduce dose and extend dosing interval
use with caution, reduce dose by 50% in severe impairment
monitor renal function and adjust dose accordingly
Use with caution and monitor for adverse effects.
hepatic_impairment
moderate to severereduce dose by 50%
use with caution due to impaired metabolism
monitor liver function and for signs of toxicity
Use with caution and monitor for adverse effects.
alcohol_users
concurrent useavoid combination
do not consume alcohol while using opium
monitor for severe CNS and respiratory depression
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
Opium is a controlled substance and not commonly prescribed in modern practice
Drug class
Opioid analgesic classification
Common uses
Historical and current applications
US Controlled Substance Schedule
Legal classification in the United States
Treatment of severe abdominal pain and cramping associated with gastrointestinal spasms, irritable bowel syndrome, and other conditions involving intestinal smooth muscle hyperactivity.
The opium component provides analgesic effects through morphine, while belladonna extract delivers anticholinergic alkaloids (atropine and scopolamine) that reduce smooth muscle spasms in the gastrointestinal tract through muscarinic receptor blockade.
This is a controlled substance with potential for dependence. Use is typically reserved for severe cases. Common side effects include dry mouth, constipation, urinary retention, and blurred vision. Should be used with caution in patients with glaucoma, urinary obstruction, or those taking other anticholinergic medications.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy