Oprelvekin
Oprelvekin is a recombinant human interleukin-11 (IL-11) used as a thrombopoietic growth factor to stimulate platelet production. It is primarily prescribed to prevent severe thrombocytopenia and reduce the need for platelet transfusions in patients undergoing chemotherapy.
A growth factor that stimulates platelet production to prevent chemotherapy-induced thrombocytopenia.
Key facts at a glance
- ATC
- L03AC02
- RxNorm
- 139994
- Generic
- Oprelvekin
- Class
- atc-l03
- Brands
- Neumega
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of severe thrombocytopenia in patients with nonmyeloid malignancies receiving chemotherapy, reducing the risk of bleeding complications and need for platelet transfusions.
Acts as a thrombopoietic growth factor by binding to interleukin-11 receptors on megakaryocyte progenitor cells, stimulating their proliferation and differentiation into mature platelets.
Administered by subcutaneous injection. Contraindicated in patients with congestive heart failure or cardiac disease due to risk of fluid retention. Common adverse effects include peripheral edema, dyspnea, and tachycardia. Should be discontinued if severe allergic reactions occur.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy