Elagolix
Orilissa (elagolix) is a prescription brand-name medication used to treat moderate to severe pain associated with endometriosis. It belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) receptor antagonists and works by reducing estrogen production, which helps decrease the growth of endometrial tissue and associated pain.
Orilissa is a GnRH receptor antagonist used to manage moderate to severe endometriosis pain by lowering estrogen levels.
Key facts at a glance
- RxNorm
- 2049853
- Generic
- Orilissa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Orilissa is FDA-approved for the management of moderate to severe pain associated with endometriosis. It is used in women of reproductive age and may be prescribed when other treatments have not provided adequate relief.
Orilissa works as a GnRH receptor antagonist, blocking GnRH receptors in the pituitary gland. This leads to reduced secretion of gonadotropins (LH and FSH), which decreases ovarian estrogen production. Lower estrogen levels help reduce the growth and inflammatory activity of endometrial implants, thereby decreasing associated pain.
Orilissa may cause side effects including hot flashes, night sweats, headache, and mood changes. Due to its estrogen-lowering effects, it may impact bone mineral density with prolonged use. The medication is contraindicated during pregnancy and women of reproductive potential should use effective contraception during treatment. Liver function monitoring may be required. Patients should discuss their complete medical history with their healthcare provider before starting this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy