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Published: July 26, 2026Updated: July 26, 2026

Orlynvah is a prescription antiemetic medication combining fosnetupitant and palonosetron, designed to prevent acute and delayed chemotherapy-induced nausea and vomiting. It is used in adult patients receiving chemotherapy regimens associated with a high risk of these side effects. The medication is administered as a single intravenous infusion before the start of chemotherapy.

Quick summary

Orlynvah is a combination antiemetic used to prevent chemotherapy-related nausea and vomiting.

Medically reviewed by WellAlly Editorial TeamLast reviewed July 26, 2026Editorial policy

Key facts at a glance

RxNorm
2717844
Generic
Orlynvah
Class
brand-name
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy in adult patients.

Combines two antiemetic agents: fosnetupitant (a neurokinin-1 receptor antagonist that blocks substance P) and palonosetron (a 5-hydroxytryptamine-3 receptor antagonist that blocks serotonin), targeting different pathways involved in chemotherapy-induced nausea and vomiting.

Administered as a single IV infusion approximately 30 minutes before chemotherapy. May cause headache, constipation, or fatigue. Patients should inform their healthcare provider of all medications and medical conditions before use. Safety in pregnancy has not been established.

Official drug label

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Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy