Sodium Hyaluronate
Orthovisc is an injectable hyaluronic acid product used to treat knee pain caused by osteoarthritis. It works as a viscosupplement, providing lubrication and cushioning to the knee joint when the natural synovial fluid has degraded due to osteoarthritis. The medication is typically administered as a series of injections directly into the knee joint by a healthcare professional.
Orthovisc is an injectable hyaluronic acid treatment for knee osteoarthritis that supplements the joint's lubricating fluid to reduce pain and improve mobility.
Key facts at a glance
- RxNorm
- 398331
- Generic
- Orthovisc
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Orthovisc is indicated for the treatment of pain associated with osteoarthritis of the knee, particularly in patients who have not responded adequately to conservative treatments such as physical therapy, exercise, or over-the-counter pain medications.
Orthovisc contains highly purified hyaluronic acid, a natural substance found in synovial fluid. In osteoarthritis, the quality and quantity of hyaluronic acid in the joint decreases, reducing the fluid's lubricating and cushioning properties. Orthovisc supplements this degraded synovial fluid, helping to restore joint lubrication and shock absorption, which can reduce pain and improve joint function.
Orthovisc is administered as a series of injections (typically 3-4 injections given one week apart) directly into the knee joint. Common side effects may include temporary injection site pain, swelling, or stiffness. It should not be used in patients with known hypersensitivity to hyaluronic acid products or in cases of knee joint infection. Patients should consult their healthcare provider to determine if Orthovisc is appropriate for their individual condition.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy