Methotrexate
Otrexup is a brand-name formulation of methotrexate delivered via subcutaneous injection, designed for self-administration in patients with certain autoimmune conditions. It is primarily used to treat rheumatoid arthritis, psoriasis, and polyarticular juvenile idiopathic arthritis by helping to reduce inflammation and slow disease progression.
Otrexup is a prescription methotrexate injection used to treat autoimmune conditions like rheumatoid arthritis and psoriasis.
Key facts at a glance
- RxNorm
- 1441403
- Generic
- Otrexup
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Otrexup is indicated for the treatment of rheumatoid arthritis, psoriasis (including psoriatic arthritis), and polyarticular juvenile idiopathic arthritis in patients who have not responded adequately to other therapies.
As a folate antagonist, methotrexate inhibits dihydrofolate reductase, disrupting DNA synthesis and cell reproduction. In autoimmune conditions, this immunosuppressive effect helps reduce the abnormal immune response that causes inflammation and tissue damage.
Otrexup is administered as a weekly subcutaneous injection. It carries significant risks including liver toxicity, bone marrow suppression, and fetal harm, requiring regular monitoring and strict contraception use. Patients should avoid alcohol and have periodic blood tests to assess liver function and blood cell counts.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy