Cenegermin
Oxervate is a brand-name ophthalmic solution containing cenegermin, a recombinant human nerve growth factor. It is specifically indicated for the treatment of neurotrophic keratitis, a rare degenerative eye condition characterized by poor corneal healing due to impaired nerve function. The medication is administered as eye drops directly to the affected eye(s) to promote corneal repair and restore ocular surface integrity.
Oxervate is a topical eye medication used to treat neurotrophic keratitis by delivering nerve growth factor to promote corneal healing.
Key facts at a glance
- RxNorm
- 2104337
- Generic
- Oxervate
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Oxervate is indicated for the treatment of neurotrophic keratitis, a rare and serious ocular condition in which the cornea loses sensation and fails to heal properly due to damage to the trigeminal nerve. This condition can lead to corneal ulcers, perforation, and vision loss if left untreated.
Oxervate contains cenegermin, a recombinant form of human nerve growth factor (NGF) that is identical to the naturally occurring protein. When applied topically to the eye, cenegermin binds to specific receptors on corneal nerve cells, promoting the survival, growth, and regeneration of corneal nerves. This helps restore corneal sensitivity and supports the natural healing process of the corneal epithelium.
Oxervate is for topical ophthalmic use only and should be applied exactly as prescribed by a healthcare provider. Common side effects may include eye pain, redness, inflammation, and increased tearing. Patients should wash hands before application and avoid contamination of the dropper tip. Treatment is typically continued for a specified duration as determined by the prescribing physician. Patients should inform their doctor of any other eye conditions or medications before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy