Lumasiran
Oxlumo (lumasiran) is a prescription medication used to treat primary hyperoxaluria type 1 (PH1) in adults and children of all ages. PH1 is a rare genetic disorder where the liver produces excessive amounts of oxalate, leading to recurrent kidney stones, kidney damage, and potentially systemic complications. Oxlumo works by reducing oxalate production, thereby decreasing the risk of kidney damage and other associated complications.
Oxlumo is a medication for primary hyperoxaluria type 1 that reduces oxalate production to prevent kidney damage and stones.
Key facts at a glance
- RxNorm
- 2467154
- Generic
- Oxlumo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Oxlumo is indicated for the treatment of primary hyperoxaluria type 1 (PH1), a rare inherited disorder characterized by excessive oxalate production in the liver. This condition leads to recurrent kidney stones, progressive kidney damage, and potentially systemic oxalosis affecting other organs.
Oxlumo is a glycolate oxidase (GO) inhibitor that works by targeting and reducing the activity of the GO enzyme in the liver. By inhibiting this enzyme, the medication decreases the conversion of glycolate to oxalate, thereby lowering oxalate production and accumulation in the body.
Oxlumo is administered via subcutaneous injection, typically with loading doses followed by maintenance doses every other month. Treatment should be initiated by a healthcare provider experienced in managing PH1. Patients require regular monitoring of oxalate levels and kidney function. Common side effects may include injection site reactions, abdominal pain, and headache. Adequate hydration is important during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy