Ozanimod
Ozanimod is a sphingosine 1-phosphate (S1P) receptor modulator approved for treating relapsing forms of multiple sclerosis and moderately to severely active ulcerative colitis. By binding to S1P receptors 1 and 5, it prevents lymphocytes from exiting lymph nodes, thereby reducing immune-mediated inflammation in the central nervous system and gastrointestinal tract.
Ozanimod is an immunomodulating medication that treats MS and ulcerative colitis by trapping immune cells in lymph nodes to reduce inflammatory damage.
Key facts at a glance
- ATC
- L04AE02
- RxNorm
- 2288236
- Generic
- Ozanimod
- Class
- atc-l04
- Brands
- Zeposia
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ozanimod is indicated for the treatment of relapsing forms of multiple sclerosis (MS) and moderately to severely active ulcerative colitis (UC).
Ozanimod is an S1P receptor modulator that binds with high affinity to sphingosine 1-phosphate receptors 1 and 5. This binding prevents lymphocytes from egressing from lymph nodes, reducing the number of circulating lymphocytes available to cause inflammation in target tissues.
Requires first-dose cardiac monitoring due to potential transient heart rate reduction; liver function monitoring needed; may increase susceptibility to infections; contraindicated in pregnancy; gradual dose titration required to reach maintenance dose.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy