Pegvaliase-pqpz
Palynziq is a prescription enzyme substitution therapy used to treat adults with phenylketonuria (PKU) who have uncontrolled blood phenylalanine levels despite dietary restrictions. It works by providing an enzyme that breaks down the amino acid phenylalanine, helping to reduce toxic accumulation in the body.
Palynziq is an injectable enzyme therapy for adults with uncontrolled PKU that helps lower dangerous phenylalanine levels in the blood.
Key facts at a glance
- RxNorm
- 2046366
- Generic
- Palynziq
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Palynziq is indicated for adults with phenylketonuria (PKU) who have inadequate blood phenylalanine control (typically >600 μmol/L) despite dietary management or other treatments. It is specifically approved for patients 18 years and older.
Palynziq contains pegvaliase-pqpz, a recombinant PEGylated phenylalanine ammonia lyase (PAL) enzyme. This enzyme converts phenylalanine into trans-cinnamic acid and ammonia, effectively metabolizing and reducing circulating phenylalanine levels in the blood.
Palynziq is administered via subcutaneous injection. Common side effects include injection site reactions, arthralgia, hypersensitivity reactions, and headache. Patients require monitoring of blood phenylalanine levels and may need to continue dietary phenylalanine restriction. Treatment initiation requires a slow dose escalation protocol and carries a risk of severe allergic reactions, including anaphylaxis.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy