Nortriptyline
Pamelor (nortriptyline) is a tricyclic antidepressant used to treat major depressive disorder and other mood conditions. It works by increasing certain natural substances in the brain to help restore mental balance. This medication may also be prescribed for nerve pain (neuropathic pain) and prevention of chronic headaches such as migraines.
Pamelor is a tricyclic antidepressant used for depression and certain types of chronic pain.
Key facts at a glance
- RxNorm
- 7866
- Generic
- Pamelor
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pamelor is primarily prescribed for major depressive disorder. It may also be used off-label for neuropathic pain conditions, migraine prevention, and sometimes for attention deficit disorders or smoking cessation when other treatments are not suitable.
As a tricyclic antidepressant, Pamelor works by inhibiting the reuptake of neurotransmitters norepinephrine and serotonin in the brain, increasing their availability. This action helps regulate mood and can influence pain signals in the nervous system.
Pamelor may cause drowsiness, dry mouth, blurred vision, and constipation. It requires careful monitoring in patients with heart conditions due to potential cardiac effects. This medication should not be stopped abruptly, and patients should be monitored for worsening depression or suicidal thoughts, particularly when starting treatment. Inform your doctor of all current medications to avoid harmful interactions.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy