Pazopanib
Pazopanib is an oral multi-targeted tyrosine kinase inhibitor used to treat advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma. It works by blocking multiple enzymes (tyrosine kinases) that tumors need to grow blood vessels and multiply, slowing tumor growth and progression.
An oral cancer medication that inhibits multiple growth signals to treat kidney cancer and soft tissue sarcoma.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01EX03
- RxNorm
- 714438
- Generic
- Pazopanib
- Class
- atc-l01
- Brands
- Votrient
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of advanced renal cell carcinoma (clear cell type) and advanced soft tissue sarcoma in patients who have received prior chemotherapy.
Inhibits multiple tyrosine kinase receptors including VEGFR-1, -2, and -3 (vascular endothelial growth factor receptors), PDGFR-α and -β, FGFR-1 and -3, Kit, and interleukin-2 receptor. This blocks tumor angiogenesis (new blood vessel formation) and tumor cell proliferation.
Taken once daily on an empty stomach (at least 1 hour before or 2 hours after food). Requires regular monitoring of liver function, blood pressure, and cardiac function. May cause serious side effects including hepatotoxicity, cardiac toxicity, hemorrhage, and gastrointestinal perforation. Should not be used during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy