Pemetrexed
Pemfexy is a brand-name chemotherapy medication containing pemetrexed, a folate analog antimetabolite that interferes with cancer cell DNA synthesis. It is used to treat certain types of cancer, including malignant pleural mesothelioma and non-small cell lung cancer, typically in combination with other chemotherapy agents.
Pemfexy is a prescription chemotherapy drug used to treat specific cancers by disrupting cancer cell growth and division.
Key facts at a glance
- RxNorm
- 2590673
- Generic
- Pemfexy
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pemfexy is indicated for the treatment of malignant pleural mesothelioma (in combination with cisplatin) and locally advanced or metastatic non-small cell lung cancer (NSCLC). It may be used as initial treatment, maintenance therapy, or as a second-line treatment depending on the cancer type and patient circumstances.
Pemfexy contains pemetrexed, which acts as a folate antagonist that inhibits multiple enzymes involved in DNA synthesis, including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. By disrupting these key pathways, it prevents cancer cells from multiplying effectively.
Pemfexy is administered by intravenous infusion by a healthcare professional. Patients typically receive vitamin B12 and folic acid supplementation before and during treatment to reduce side effects. Regular blood monitoring is required during treatment. Common side effects may include fatigue, nausea, and low blood cell counts. This medication should only be used under the supervision of an oncologist experienced in chemotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy