Pemoline
Pemoline is a central nervous system stimulant that was primarily used to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents, as well as narcolepsy. It works by increasing dopamine activity in the brain. Due to significant safety concerns regarding liver toxicity, pemoline has been withdrawn from the market in most countries.
Pemoline is a discontinued CNS stimulant previously used for ADHD that was removed from markets due to serious liver toxicity risks.
Key facts at a glance
- ATC
- N06BA05
- RxNorm
- 7966
- Generic
- Pemoline
- Class
- atc-n06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pemoline was indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents, and was also sometimes prescribed for narcolepsy and excessive daytime sleepiness.
Pemoline is a CNS stimulant that works by enhancing dopaminergic and noradrenergic neurotransmission in the brain, increasing alertness and attention while reducing hyperactivity and impulsive behavior.
Pemoline has been discontinued in most countries including the United States due to rare but serious cases of acute liver failure. Regular liver function monitoring was required during treatment. Common side effects included insomnia, decreased appetite, and weight loss. It was contraindicated in patients with liver impairment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy