Penbutolol
Penbutolol is a non-selective beta-blocker medication used primarily to treat high blood pressure (hypertension). It works by blocking the effects of adrenaline on beta-adrenergic receptors in the heart and blood vessels, which reduces heart rate and blood pressure. This medication may be prescribed when other first-line antihypertensives are not adequately controlling blood pressure or are not well-tolerated.
Penbutolol is a beta-blocker used to treat hypertension by reducing heart rate and cardiac output.
Key facts at a glance
- ATC
- C07AA23
- RxNorm
- 7973
- Generic
- Penbutolol
- Class
- atc-c07
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Penbutolol is primarily indicated for the treatment of essential hypertension (high blood pressure). It may be used as monotherapy or in combination with other antihypertensive agents when single-agent therapy is insufficient.
Penbutolol is a non-selective beta-blocker that competitively antagonizes both beta-1 and beta-2 adrenergic receptors. It reduces heart rate, decreases cardiac output, and lowers blood pressure. The medication also possesses intrinsic sympathomimetic activity (ISA), meaning it has partial agonist properties at beta receptors.
Penbutolol should not be discontinued abruptly as this may precipitate angina, myocardial infarction, or rebound hypertension. It should be used with caution in patients with asthma, diabetes, or heart failure. Common side effects may include fatigue, bradycardia, and cold extremities. This medication is contraindicated in patients with severe bradycardia, AV block, or decompensated heart failure.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy