Diclofenac Sodium
Pennsaid is a topical nonsteroidal anti-inflammatory drug (NSAID) containing diclofenac sodium, available as a 2% solution or gel. It is applied directly to the skin over painful joints to reduce pain and inflammation associated with osteoarthritis, particularly of the knee.
Pennsaid is a topical NSAID gel/solution used to treat osteoarthritis pain in the knees by applying medication directly to the affected joint.
Key facts at a glance
- RxNorm
- 967941
- Generic
- Pennsaid
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pennsaid is primarily indicated for the treatment of pain and inflammation associated with osteoarthritis of the knee. The 2% topical solution is specifically approved for this use, providing localized relief for joint pain and stiffness.
As an NSAID, Pennsaid contains diclofenac sodium, which works by inhibiting cyclooxygenase (COX) enzymes. This reduces the production of prostaglandins—chemicals involved in pain and inflammation—providing analgesic and anti-inflammatory effects directly at the site of application.
Pennsaid is for topical use only and should not be applied to broken or damaged skin. While systemic absorption is minimized compared to oral NSAIDs, side effects may still occur including skin irritation at the application site. Patients with aspirin-sensitive asthma, pregnancy in third trimester, or those on other anticoagulants should use with caution. Avoid contact with eyes and mucous membranes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy