Penpulimab
Penpulimab is a monoclonal antibody immunotherapy that works as a PD-1 inhibitor to help restore the immune system's ability to recognize and attack cancer cells. By blocking the PD-1 pathway, it prevents tumor cells from evading immune detection, allowing T-cells to remain active against malignancies. This medication is used in the treatment of certain cancers where the PD-1/PD-L1 pathway contributes to immune suppression.
Penpulimab is a PD-1 inhibitor immunotherapy drug that helps the immune system fight cancer by blocking a pathway tumors use to escape detection.
Key facts at a glance
- RxNorm
- 2712542
- Generic
- Penpulimab
- Class
- unclassified
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Penpulimab is indicated for the treatment of relapsed or refractory classical Hodgkin lymphoma and may be used for other malignancies as determined by treating oncologists based on clinical evidence.
Penpulimab binds to the PD-1 receptor on T-cells, blocking interaction with PD-L1 and PD-L2 ligands on tumor cells. This removes the brake on T-cell activity, restoring T-cell proliferation and cytokine production to mount an anti-tumor immune response.
As an immunotherapy, penpulimab may cause immune-related adverse events affecting various organ systems. Patients should be monitored for pneumonitis, colitis, hepatitis, and endocrine disorders. Treatment should be administered by healthcare professionals experienced in cancer immunotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy