Pentobarbital
Pentobarbital is a barbiturate that acts as a central nervous system depressant, producing sedation, hypnosis, and anticonvulsant effects. It is used in clinical settings primarily for preoperative sedation, seizure control, and as an induction agent for anesthesia.
Pentobarbital is a barbiturate sedative used for sedation, seizure control, and anesthesia induction.
Key facts at a glance
- ATC
- N05CA01
- RxNorm
- 8004
- Generic
- Pentobarbital
- Class
- atc-n05
- Brands
- Euthasol, Fatal-Plus, Nembutal, Euthaphen, Pentobarsol
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, rectal
- Forms
- capsule, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for preoperative sedation, control of status epilepticus and other seizure disorders, induction of general anesthesia, and short-term treatment of insomnia.
Acts as a positive allosteric modulator at GABA-A receptors, enhancing the inhibitory effects of GABA and reducing neuronal excitability throughout the central nervous system.
Has a narrow therapeutic index with risk of respiratory depression, dependence, and tolerance. Requires careful dosing and monitoring. Contraindicated in patients with porphyria, severe respiratory insufficiency, and should be used with caution in elderly or debilitated patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy