Pentoxifylline
Pentoxifylline is a xanthine derivative that improves blood flow to the extremities by reducing blood viscosity and increasing red blood cell flexibility. It is primarily used to treat symptoms of peripheral arterial disease, particularly intermittent claudication (leg pain during walking).
Pentoxifylline is a vasodilator used to improve circulation in patients with peripheral vascular disease.
Key facts at a glance
- ATC
- C04AD03
- RxNorm
- 8013
- Generic
- Pentoxifylline
- Class
- atc-c04
- Brands
- —
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pentoxifylline is used to treat symptomatic peripheral arterial disease, particularly intermittent claudication characterized by leg pain, cramping, or weakness during physical activity due to impaired blood flow to the limbs.
Pentoxifylline is a methylxanthine derivative that improves microcirculation by reducing blood viscosity, increasing erythrocyte flexibility, and mildly inhibiting platelet aggregation. These effects enhance oxygen delivery to tissues in the extremities.
Pentoxifylline is typically administered as extended-release tablets. Common side effects include gastrointestinal disturbances (nausea, vomiting), dizziness, and headache. It is contraindicated in patients with recent cerebral or retinal hemorrhage and should be used cautiously in those with coronary artery disease. Patients should be advised that symptomatic improvement may take several weeks of consistent therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy