Oxycodone, Acetaminophen
Percocet is a prescription combination medication containing oxycodone (an opioid) and acetaminophen (Tylenol). It is used to manage moderate to severe pain when other pain relievers are not effective. The medication works by targeting opioid receptors in the brain to reduce pain perception while also reducing fever through its acetaminophen component.
Percocet is an opioid-based pain medication used for short-term management of moderate to severe pain.
Key facts at a glance
- RxNorm
- 42844
- Generic
- Percocet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Percocet is prescribed for the management of moderate to severe pain, typically when other non-opioid pain medications have not provided adequate relief. It is generally intended for short-term use due to the risk of dependence.
The oxycodone component binds to opioid receptors in the brain and central nervous system, altering the perception of pain and the emotional response to discomfort. The acetaminophen component contributes to pain relief and also reduces fever through different mechanisms.
Percocet is a Schedule II controlled substance with significant risks of dependence, addiction, and overdose. Common side effects include drowsiness, constipation, nausea, and respiratory depression. The acetaminophen component can cause serious liver damage if taken in excessive amounts. It should only be used exactly as prescribed by a healthcare provider and never combined with alcohol or other central nervous system depressants.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy