Pergolide
Pergolide is a dopamine agonist used primarily to treat Parkinson's disease. It works by stimulating dopamine receptors in the brain, helping to restore dopamine function and improve motor symptoms such as tremor, stiffness, and slowness of movement. Note: This medication has been withdrawn from the US market and many other countries due to concerns about heart valve damage.
Pergolide is a dopamine agonist formerly used to treat Parkinson's disease, now largely withdrawn from markets due to cardiac safety concerns.
Key facts at a glance
- ATC
- N04BC02
- RxNorm
- 8047
- Generic
- Pergolide
- Class
- atc-n04
- Brands
- Prascend, Zygolide
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Parkinson's disease (formerly first-line treatment, now rarely used due to safety concerns); previously also used for hyperprolactinemia and restless legs syndrome
Acts as a dopamine receptor agonist, primarily stimulating D2 receptors in the brain to compensate for dopamine deficiency characteristic of Parkinson's disease
Withdrawn from US market in 2007 due to risk of heart valve damage; requires cardiac monitoring if used; should not be stopped abruptly; has been largely replaced by safer alternatives such as pramipexole and ropinirole
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy