Chlorhexidine Gluconate
Periogard is an antimicrobial oral rinse containing chlorhexidine gluconate, used to help control bacteria in the mouth and treat gingivitis (gum inflammation). It is typically prescribed for short-term use following dental procedures or for managing oral infections.
Periogard is a prescription antimicrobial mouthwash used to reduce oral bacteria and treat gum inflammation.
Key facts at a glance
- RxNorm
- 219169
- Generic
- Periogard
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Periogard is used to treat gingivitis (gum inflammation characterized by redness, swelling, and bleeding of the gums). It is also commonly prescribed as a post-procedural rinse following dental surgery or other dental procedures to help reduce the risk of infection and control plaque accumulation.
As an antimicrobial agent, Periogard (chlorhexidine gluconate) works by binding to oral tissues and slowly releasing over time, where it disrupts bacterial cell membranes and kills a broad spectrum of oral bacteria, helping to reduce plaque formation and gingival inflammation.
Periogard is typically used twice daily as a rinse (usually 15mL swished for 30-60 seconds). Common side effects may include tooth discoloration, altered taste, and increased tartar formation. It should not be used by individuals with known hypersensitivity to chlorhexidine. Prolonged use should be monitored by a dental professional, as it may affect taste perception.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy