Pexidartinib
Pexidartinib is an oral tyrosine kinase inhibitor used to treat symptomatic tenosynovial giant cell tumor (TGCT), a rare non-cancerous tumor that affects joints and tendon sheaths. It works by blocking specific signaling pathways involved in tumor cell growth and proliferation.
Pexidartinib is a targeted therapy for tenosynovial giant cell tumor that inhibits CSF1R, KIT, and FLT3 to reduce tumor growth.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01EX15
- RxNorm
- 2183102
- Generic
- Pexidartinib
- Class
- atc-l01
- Brands
- Turalio
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of symptomatic tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis (PVNS), in adults where surgery would cause functional limitation or severe morbidity.
Pexidartinib inhibits colony stimulating factor 1 receptor (CSF1R), KIT, and FLT3 with ITD mutations. By blocking CSF1R, it reduces the abnormal cell proliferation that drives TGCT tumor growth.
Associated with risk of serious and potentially fatal liver injury requiring regular hepatic monitoring. Contraindicated in patients with pre-existing severe hepatic impairment. May cause fetal harm; contraception required during treatment and for one month after. Available only through a restricted distribution program.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy