Promethazine
Phenergan (promethazine) is a first-generation antihistamine medication used to treat allergic conditions, nausea, vomiting, and motion sickness. It also serves as a sedative and is sometimes used before or after surgery. This medication is available by prescription and works by blocking histamine receptors in the body.
Phenergan is an antihistamine used for allergies, nausea, vomiting, motion sickness, and as a sedative.
Key facts at a glance
- RxNorm
- 152218
- Generic
- Phenergan
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats allergic reactions, hay fever, allergic rhinitis, allergic skin conditions, motion sickness, nausea and vomiting, and is used as a sedative or preoperative medication.
Blocks histamine H1 receptors in the body, reducing allergic symptoms. It also has anticholinergic effects that help reduce nausea and vomiting, and produces central nervous system depression leading to sedation.
May cause drowsiness; avoid alcohol and operating machinery. Not recommended for children under 2 years due to risk of breathing problems. Should not be used in patients with certain medical conditions; inform your doctor of all current medications and health conditions before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy