Phenyl Salicylate
Phenyl Salicylate is a salicylate ester that has been used as a urinary antiseptic and analgesic for treating urinary tract infections. It acts locally in the urinary system to help reduce bacterial growth and provide symptomatic relief. This medication is considered an older agent and is not commonly prescribed in modern practice.
An older urinary antiseptic medication used to treat and prevent urinary tract infections.
Key facts at a glance
- ATC
- G04BX12
- RxNorm
- 36122
- Generic
- Phenyl Salicylate
- Class
- atc-g04
- Brands
- Hyophen, Phosphasal, Ustell, Prosed DS, Urimar Reformulated Oct 2013, Urin DS, Uretron DS, Uribel Tabs, Urelle, Utira, Uribel
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
9 groupspregnancy
first trimesteravoid high doses
use only if benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid use
contraindicated near term due to risk of prolonged bleeding time and possible closure of ductus arteriosus
fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedinguse with caution
avoid prolonged use; short-term use may be acceptable if needed
monitor infant for signs of salicylate toxicity
Use with caution and monitor for adverse effects.
pediatric_age
children under 12use with caution; avoid in viral infections
avoid in children with viral illnesses due to Reye syndrome risk
monitor for signs of Reye syndrome
Use with caution and monitor for adverse effects.
geriatric
elderly over 65reduce dose; start at low end of dosing range
use with caution due to increased sensitivity and reduced renal clearance
monitor renal function and for signs of GI bleeding
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderateadjust dose based on creatinine clearance
reduce dose; monitor renal function
regular monitoring of renal function and serum salicylate levels
Use with caution and monitor for adverse effects.
renal_impairment
severeavoid or significantly reduce dose
use not recommended in severe renal impairment
frequent monitoring of renal function
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild to moderatereduce dose
use with caution; may require dose reduction
monitor liver function tests
Use with caution and monitor for adverse effects.
alcohol_users
chronic alcohol useavoid concomitant use
avoid alcohol during treatment due to increased GI bleeding risk
monitor for signs of GI bleeding
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological mechanism
Phenyl Salicylate has been used for the treatment and prevention of urinary tract infections, particularly lower urinary tract infections. It may also be used for symptomatic relief of urinary discomfort.
Phenyl Salicylate is a salicylate derivative that releases salicylic acid upon hydrolysis. The salicylate component is partially excreted in the urine, where it provides local antiseptic effects against bacteria commonly causing UTIs.
This is an older medication with limited use in contemporary practice. As a salicylate derivative, it should be used with caution in patients with aspirin sensitivity, renal impairment, or those taking other salicylate medications. Not recommended during pregnancy without medical supervision.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy