Pertuzumab, Trastuzumab, Hyaluronidase-zzxf
Phesgo is a brand-name medication used to treat HER2-positive breast cancer. It combines two monoclonal antibodies (pertuzumab and trastuzumab) with hyaluronidase, administered as a subcutaneous injection. This targeted therapy is used in both early and metastatic HER2-positive breast cancer, typically in combination with chemotherapy.
Phesgo is a subcutaneous injection medication combining two HER2-targeting antibodies used to treat HER2-positive breast cancer.
Key facts at a glance
- RxNorm
- 2382605
- Generic
- Phesgo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Phesgo is indicated for the treatment of HER2-positive early breast cancer (as neoadjuvant/adjuvant therapy) and metastatic HER2-positive breast cancer. Treatment is typically given in combination with chemotherapy.
Phesgo contains two monoclonal antibodies (pertuzumab and trastuzumab) that bind to the HER2 receptor on cancer cells, blocking signals that promote cancer cell growth and survival. The hyaluronidase component facilitates subcutaneous delivery of these large molecules.
Administered as a subcutaneous injection, typically every 3 weeks. Requires HER2-positive status confirmation before treatment. Patients should be monitored for heart function during treatment as cardiotoxicity is possible. May cause infusion-related reactions. Must be stored properly and administered by healthcare professionals.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy