Phexxi
Phexxi is a prescription contraceptive gel designed to prevent pregnancy when inserted into the vagina before sexual intercourse. Unlike hormonal birth control methods, it uses a novel approach by maintaining an acidic vaginal environment that inhibits sperm motility. This makes it a hormone-free option for women seeking an on-demand method of contraception.
Phexxi is a hormone-free prescription vaginal gel contraceptive that prevents pregnancy by creating an acidic environment harmful to sperm.
Key facts at a glance
- RxNorm
- 2385349
- Generic
- Phexxi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Phexxi is indicated for the prevention of pregnancy in women of reproductive age who wish to use a non-hormonal, on-demand contraceptive method. It is not effective against sexually transmitted infections.
Phexxi contains lactic acid, citric acid, and potassium bitartrate, which work together to maintain an acidic vaginal pH (approximately 3.5-4.5). This acidic environment reduces sperm motility and viability, preventing fertilization.
Phexxi must be inserted into the vagina before each act of intercourse. It is a prescription-only medication and should not be used by women who are pregnant or trying to conceive. Patients with recurrent urinary tract infections or vaginal infections should consult their healthcare provider before use. Effectiveness varies; clinical trials showed it was about 86% effective with typical use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy