Riboflavin, Tryptophan,-
Photrexa is a sterile ophthalmic solution containing riboflavin (vitamin B2) that is used in corneal cross-linking procedures to treat progressive keratoconus and corneal ectasia. During the procedure, the medication is applied to the cornea and activated with UV-A light to strengthen corneal tissue by creating new cross-links between collagen fibers. This brand-name medication is reserved for use in clinical settings by trained eye care professionals.
Photrexa is an ophthalmic riboflavin solution used during corneal cross-linking procedures to halt progression of keratoconus and corneal ectasia.
Key facts at a glance
- RxNorm
- 1925826
- Generic
- Photrexa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Photrexa is indicated for the treatment of progressive keratoconus and corneal ectasia following refractive surgery. It is used as part of the corneal cross-linking procedure to increase corneal rigidity and halt disease progression.
Photrexa contains riboflavin 5'-phosphate, a photosensitizer that absorbs UV-A light. When activated by UV-A radiation, it generates reactive oxygen species that facilitate the formation of covalent bonds between collagen fibrils in the cornea, thereby increasing biomechanical strength and resistance to enzymatic degradation.
Photrexa is administered topically to the cornea during a supervised medical procedure and is not intended for self-administration. It must be used with appropriate UV-A light exposure using a certified delivery system. The procedure is typically performed by ophthalmologists experienced in corneal cross-linking. Potential risks include corneal epithelial injury, stromal haze, and other procedure-related complications. Patient eligibility requires careful evaluation including corneal thickness assessment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy