Doravirine
Pifeltro (doravirine) is a brand-name antiretroviral medication classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection in adults. It is typically used in combination with other antiretroviral drugs as part of a complete treatment regimen. This medication helps reduce the amount of HIV in the body, allowing the immune system to function more effectively.
Pifeltro is an HIV medication that works by blocking an enzyme the virus needs to multiply, helping control HIV infection when used with other antiretrovirals.
Key facts at a glance
- RxNorm
- 2055761
- Generic
- Pifeltro
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pifeltro is indicated for the treatment of HIV-1 infection in adults without prior antiretroviral treatment history, or in those who have been treated with other HIV medications but require a new regimen. It must always be used in combination with other antiretroviral drugs and is not appropriate for use alone.
As an NNRTI, Pifeltro works by inhibiting the reverse transcriptase enzyme of HIV-1. By blocking this enzyme, the medication prevents the conversion of viral RNA into DNA, which is essential for the virus to replicate and spread throughout the body.
Pifeltro does not cure HIV infection or AIDS and should not be used as monotherapy. Patients should be aware that it may not prevent HIV transmission to others. Common side effects may include dizziness, nausea, and abnormal dreams. This medication may interact with other drugs, so patients should inform their healthcare provider of all medications and supplements they are taking.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy