Pimavanserin
Pimavanserin is an atypical antipsychotic medication used to treat hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Unlike traditional antipsychotics, it works by targeting serotonin 5-HT2A receptors rather than dopamine receptors, making it suitable for patients with Parkinson's disease. It is FDA-approved specifically for this indication and is available as an oral tablet.
Pimavanserin is a non-dopamine antipsychotic used to treat hallucinations and delusions in Parkinson's disease patients.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AX17
- RxNorm
- 1791685
- Generic
- Pimavanserin
- Class
- atc-n05
- Brands
- Nuplazid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pimavanserin is indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis (PDP). It is the first and only FDA-approved medication specifically for this condition.
Pimavanserin acts as an inverse agonist and antagonist at serotonin 5-HT2A receptors. By blocking these receptors, it reduces psychotic symptoms without affecting dopamine pathways, which is particularly important for maintaining motor function in Parkinson's disease patients.
Pimavanserin is not approved for dementia-related psychosis or as a treatment for depression. Common side effects may include swelling, nausea, and confusion. It should be used with caution in patients with existing cardiac conditions or those taking CYP3A4 inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy