Pirfenidone
Pirfenidone is an oral anti-fibrotic medication used to treat idiopathic pulmonary fibrosis (IPF), a progressive and potentially fatal lung disease characterized by scarring of lung tissue. It is prescribed for patients with mild to moderate IPF to help slow disease progression and preserve lung function over time.
Pirfenidone is an anti-fibrotic medication used to slow the progression of idiopathic pulmonary fibrosis (IPF).
Key facts at a glance
- ATC
- L04AX05
- RxNorm
- 1592254
- Generic
- Pirfenidone
- Class
- atc-l04
- Brands
- Esbriet
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of idiopathic pulmonary fibrosis (IPF), a chronic, progressive, and life-threatening lung disease of unknown cause characterized by gradual scarring (fibrosis) of the lung tissue. It is indicated for use in patients with mild to moderate disease severity.
The exact mechanism of action of pirfenidone in IPF has not been established. The drug is believed to have anti-fibrotic and anti-inflammatory properties, though its specific molecular targets and pathways in the lungs have not been definitively identified.
Common side effects include nausea, rash, photosensitivity reactions, fatigue, and dizziness. Requires regular monitoring of liver function. Should be taken with food to reduce gastrointestinal side effects. May cause significant photosensitivity; sun protection is recommended. Contraindicated in patients with severe hepatic or renal impairment. Pregnancy category C - should not be used during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy