Piroxicam
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute musculoskeletal disorders.
Piroxicam is an NSAID used to treat pain and inflammation in conditions like arthritis.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- M01AC01
- RxNorm
- 8356
- Generic
- Piroxicam
- Class
- atc-m01
- Brands
- Feldene
- Availability
- rx
- Lactation
- unknown
- Routes
- topical, oral, rectal
- Forms
- gel, capsule, tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Piroxicam is used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal conditions (such as strains and sprains), and dysmenorrhea. It may also be used for other inflammatory or painful conditions as determined by a healthcare provider.
Piroxicam works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which reduces the production of prostaglandins—chemicals involved in inflammation, pain, and fever. This results in decreased inflammation, relief from pain, and reduction of fever.
Piroxicam should be used at the lowest effective dose for the shortest duration possible to minimize risks. Common side effects include gastrointestinal issues such as stomach pain and nausea. Like other NSAIDs, it may increase the risk of cardiovascular events, gastrointestinal bleeding, and kidney problems. Patients with a history of ulcers, heart disease, or kidney impairment should use with caution. Always follow prescribing physician instructions and inform them of all medications being taken.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy