Pizotyline
Pizotyline is an antimigraine medication primarily used for the preventive treatment of migraine headaches. It works as a serotonin antagonist and antihistamine, helping to reduce the frequency and severity of migraine attacks.
Pizotyline is a serotonin antagonist used to prevent migraine headaches.
Key facts at a glance
- ATC
- N02CX01
- RxNorm
- 8373
- Generic
- Pizotyline
- Class
- atc-n02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pizotyline is primarily prescribed for the prophylactic (preventive) treatment of migraine headaches and may also be used for cluster headaches. It is not typically used for acute migraine attacks but rather to reduce their frequency and severity over time.
Pizotyline acts as a serotonin 5-HT2 receptor antagonist and also has antihistamine (H1 receptor) blocking properties. These actions help modulate vascular and neuronal mechanisms involved in migraine pathogenesis, potentially reducing neurovascular inflammation and pain signaling associated with migraine attacks.
Common side effects may include drowsiness, increased appetite, and weight gain. Patients should inform their healthcare provider of any existing conditions, particularly glaucoma or urinary retention. Alcohol may enhance sedative effects. Treatment should be initiated under medical supervision with appropriate monitoring of therapeutic response.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy