Pomalidomide
Pomalidomide is an immunomodulatory drug used to treat multiple myeloma, a cancer of plasma cells. It works by binding to cereblon to modulate the immune system and inhibit cancer cell growth and blood vessel formation. It is typically used in combination with dexamethasone for patients who have received at least two prior therapies.
Pomalidomide is an immunosuppressant used to treat multiple myeloma by targeting cereblon to inhibit cancer cell growth.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L04AX06
- RxNorm
- 1369713
- Generic
- Pomalidomide
- Class
- atc-l04
- Brands
- Pomalyst
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pomalidomide is indicated for the treatment of multiple myeloma in patients who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor, in combination with dexamethasone.
Pomalidomide binds to cereblon, a component of the Cullin RING E3 ubiquitin ligase complex, leading to the degradation of specific transcription factors and resulting in immunomodulatory effects, antiangiogenic activity, and direct antineoplastic effects.
Pomalidomide is a thalidomide analogue with significant teratogenic risk and requires enrollment in a restricted distribution program (REMS). Complete blood counts should be monitored regularly due to risks of neutropenia and thrombocytopenia. Women of childbearing potential must use effective contraception during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy