Ponesimod
Ponvory (ponesimod) is a once-daily oral medication classified as a sphingosine-1-phosphate (S1P) receptor modulator, approved for the treatment of relapsing forms of multiple sclerosis (MS) in adults, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive MS. It reduces relapse frequency and helps slow disability progression.
Ponvory is an oral S1P receptor modulator used to treat relapsing forms of multiple sclerosis by reducing immune cell migration to the central nervous system.
Key facts at a glance
- RxNorm
- 2532306
- Generic
- Ponvory
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ponvory is approved for treating relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It decreases the frequency of clinical relapses and may slow disability progression.
Ponvory is a selective sphingosine-1-phosphate receptor 1 (S1P1) modulator. It binds to S1P1 receptors on lymphocytes, trapping immune cells in lymph nodes and preventing their circulation to the central nervous system, thereby reducing inflammatory damage to nerve fibers.
Ponvory is taken orally once daily. First-dose cardiac monitoring is required due to potential heart rate effects. Common side effects include upper respiratory infections, elevated liver enzymes, and hypertension. Regular blood monitoring is needed. It is contraindicated in certain cardiac conditions and pregnancy. Gradual dose titration is required when starting treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy