Necitumumab
Portrazza (necitumumab) is a monoclonal antibody medication used in combination with chemotherapy for the treatment of metastatic squamous non-small cell lung cancer (NSCLC). It works by targeting the epidermal growth factor receptor (EGFR) on cancer cells.
Portrazza is an EGFR-targeting monoclonal antibody used with chemotherapy to treat metastatic squamous non-small cell lung cancer.
Key facts at a glance
- RxNorm
- 1723746
- Generic
- Portrazza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Portrazza is indicated for the first-line treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) in combination with gemcitabine and cisplatin chemotherapy. It is specifically approved for the squamous cell carcinoma histologic subtype and is not indicated for non-squamous NSCLC.
Portrazza is a recombinant human IgG1 monoclonal antibody that binds to the extracellular domain of the epidermal growth factor receptor (EGFR). By binding to EGFR, it blocks the binding of EGFR ligands, which inhibits tumor cell growth, induces cell death, and may have antibody-dependent cellular cytotoxicity (ADCC) effects.
Portrazza carries a boxed warning for cardiopulmonary arrest and hypomagnesemia. Common side effects include skin reactions (rash, acne, pruritus), infusion-related reactions, and electrolyte abnormalities. Patients should be monitored for cardiac and pulmonary symptoms, as well as electrolyte levels during treatment. Concurrent use with radiation therapy is not recommended.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy