Pramoxine
Pramoxine is a topical anesthetic medication used to provide temporary relief from pain, itching, and discomfort associated with minor skin irritations, hemorrhoids, and anal fissures. It works by temporarily numbing the skin and mucous membranes in the area where it is applied, offering localized comfort for patients seeking relief from uncomfortable symptoms.
Pramoxine is a topical anesthetic that temporarily relieves pain and itching by numbing the skin.
Key facts at a glance
- ATC
- C05AD07
- RxNorm
- 34347
- Generic
- Pramoxine
- Class
- atc-c05
- Brands
- Vagisil Wipes, Callergy Clear, Tri Biozene, Tronolane Anesthetic, Procort 1.85/1.15, Eczemin, PrameGel Reformulated Apr 2012, New-Skin Poison Ivy, Dermal-Soothe, Cuadriderma, Analpram HC, Calaclear, Caladryl, Caladryl Clear, Calagesic
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 0
- Onset (min)
- 5
- Duration (h)
- 4
- Routes
- topical, otic, rectal
- Forms
- cream, gel, lotion, ointment, foam, spray, wipe, solution
- Regions
- United States, Canada, United Kingdom, Australia, Europe
- Monitoring
- local irritation, hypersensitivity reactions
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- apply thin layer to affected area
- Maximum
- consult physician
- Frequency
- up to 3-4 times daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- apply thin layer to affected area
- Maximum
- consult physician
- Frequency
- up to 3-4 times daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- apply thin layer to affected area
- Maximum
- consult physician
- Frequency
- up to 3-4 times daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
11 groupspregnancy
first trimesteruse lowest effective amount
avoid use during first trimester unless clearly needed, consult healthcare provider
monitor for any skin reactions
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective amount
use only if benefits outweigh risks, avoid large surface area application
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse lowest effective amount
use only if benefits outweigh risks, avoid prolonged use
monitor for any skin reactions
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid application to breast area
do not apply to breast or nipple area while breastfeeding, wash hands thoroughly before handling infant
monitor infant for any unusual reactions
Use with caution and monitor for adverse effects.
pediatric_age
children under 2use with extreme caution
consult pediatrician before use, avoid on large surface areas, do not use for prolonged periods
close monitoring for skin irritation or systemic absorption
Use with caution and monitor for adverse effects.
pediatric_age
children 2-12use as directed
follow pediatric dosing guidelines, do not apply to broken skin, avoid mucous membranes
monitor for skin irritation
geriatric
elderlyno adjustment needed
use as directed, may have thinner skin so monitor for irritation
monitor for skin sensitivity or irritation
renal_impairment
mild to moderateno adjustment needed
no specific dose adjustment required due to minimal systemic absorption
standard monitoring
renal_impairment
severeno adjustment needed
no specific dose adjustment required due to minimal systemic absorption
standard monitoring
hepatic_impairment
anyno adjustment needed
no specific dose adjustment required due to minimal systemic absorption
standard monitoring
alcohol_users
chronic alcohol useno adjustment needed
no known interaction with alcohol, use as directed
standard monitoring
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug classification information
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological mechanism
Used to relieve pain, itching, and burning associated with minor skin irritations, hemorrhoids, anal fissures, sunburn, insect bites, and poison ivy. Often found in combination products for hemorrhoid treatment.
Pramoxine is a local anesthetic that works by blocking nerve signals (sodium channels) in the applied area, temporarily numbing the skin and reducing sensation of pain and itching.
For external use only. Avoid contact with eyes, nose, and mouth. Do not apply to broken or damaged skin unless directed by a physician. Discontinue use and seek medical attention if symptoms worsen or persist beyond 7 days. May cause local skin reactions in some individuals.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy