Idarucizumab
Praxbind (idarucizumab) is a monoclonal antibody fragment designed to reverse the anticoagulant effects of Pradaxa (dabigatran). It is used in emergency situations when patients taking Pradaxa experience serious bleeding or require urgent surgery. The medication works by specifically binding to dabigatran, neutralizing its ability to inhibit thrombin.
Praxbind is a reversal agent for the blood thinner Pradaxa, used in life-threatening bleeding emergencies.
Key facts at a glance
- RxNorm
- 1716196
- Generic
- Praxbind
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Praxbind is indicated for patients taking Pradaxa (dabigatran) who experience life-threatening or uncontrolled bleeding, or who require emergency surgery or procedures where normal blood clotting must be restored quickly.
Praxbind is a monoclonal antibody fragment that binds with high affinity to dabigatran, the active ingredient in Pradaxa. By binding to dabigatran, it neutralizes the anticoagulant's ability to inhibit thrombin, allowing normal blood clot formation to resume.
Praxbind should be administered in a healthcare setting where emergency medical support is available. It is not a substitute for stopping Pradaxa therapy when appropriate. Patients should inform healthcare providers of their Pradaxa use before any procedure. Common side effects may include headache, delirium, or constipation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy