Dexmedetomidine
Precedex (dexmedetomidine) is a sedative medication primarily used in hospital settings for sedation in intensive care units and during procedural sedations. It works by binding to alpha-2 adrenergic receptors in the brain, producing sedation and anxiety relief without significant respiratory depression, making it useful for patients who require conscious sedation.
Precedex is a short-acting sedative used in hospitalized patients for ICU and procedural sedation that provides anxiety relief through alpha-2 receptor stimulation.
Key facts at a glance
- RxNorm
- 262138
- Generic
- Precedex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Precedex is used for sedation in mechanically ventilated patients in the ICU, as well as for procedural sedation in non-intubated patients undergoing surgical or diagnostic procedures. It is typically administered in settings where close monitoring is available.
Precedex works as a selective alpha-2 adrenergic receptor agonist. By stimulating these receptors in the central nervous system, it reduces sympathetic nervous system activity, resulting in decreased anxiety, sedation, and an analgesic-sparing effect. This mechanism differs from traditional sedatives that work primarily through GABA pathways.
Precedex is administered intravenously by healthcare professionals in monitored settings such as ICUs or procedural areas. Common side effects include low blood pressure, slow heart rate, and dry mouth. It may cause transient hypertension during initial dosing. Unlike many sedatives, it does not significantly suppress breathing, but patients require continuous monitoring of heart rate and blood pressure. Precedex is not approved for bolus administration for operational sedation.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy