Pretomanid
Pretomanid is an antimycobacterial medication used to treat drug-resistant forms of tuberculosis, particularly extensively drug-resistant tuberculosis (XDR-TB) and pre-XDR TB. It is typically used as part of a combination therapy regimen with other anti-tuberculosis drugs in adults when other treatments have failed.
Pretomanid is a nitroimidazooxazine antimycobacterial drug used for treating drug-resistant tuberculosis in combination with other medications.
Key facts at a glance
- ATC
- J04AK08
- RxNorm
- 2198359
- Generic
- Pretomanid
- Class
- atc-j04
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pretomanid is indicated for the treatment of pulmonary extensively drug-resistant tuberculosis (XDR-TB) and pre-XDR tuberculosis in adults, used in combination with bedaquiline and linezolid when other treatment regimens have been ineffective or are not tolerable.
As a nitroimidazooxazine antimycobacterial, Pretomanid works by inhibiting mycobacterial cell wall synthesis and other essential cellular processes in Mycobacterium tuberculosis, helping to eliminate the drug-resistant bacteria causing the infection.
Pretomanid is only available through a restricted distribution program due to its potent nature and associated risks. Liver function monitoring is recommended during treatment. Common side effects may include peripheral neuropathy, headache, and gastrointestinal symptoms. It must be used in combination with other anti-TB medications as monotherapy can lead to treatment failure and resistance.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy