Darunavir
Prezista (darunavir) is a prescription antiretroviral medication classified as an HIV protease inhibitor, used in combination with other antiretrovirals to treat HIV-1 infection in adults and children. It works by blocking the HIV protease enzyme, preventing viral replication and reducing the amount of HIV in the blood.
Prezista is an HIV protease inhibitor used with other antiretrovirals to manage HIV-1 infection.
Key facts at a glance
- RxNorm
- 643075
- Generic
- Prezista
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents. Approved for use in treatment-experienced adults and children (3 years and older), including those who have taken HIV medications before and those new to treatment.
Prezista is a protease inhibitor that binds to the HIV-1 protease enzyme, blocking its activity. This enzyme is essential for cleaving viral polyproteins into functional components needed for new viral particles. Without functional protease, HIV cannot replicate properly.
Always used with a pharmacokinetic booster (ritonavir or cobicistat) to increase effectiveness. Should be taken with food. May interact with many other medications. Not a cure for HIV and does not prevent transmission. Resistance testing is recommended before starting therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy