Ziconotide
Prialt (ziconotide) is a non-opioid pain medication derived from cone snail venom, administered via intrathecal injection directly into the spinal canal. It is prescribed for severe chronic pain in patients who have not responded to other treatments, including opioids. This medication represents an alternative mechanism for pain management when traditional options have been inadequate or poorly tolerated.
Prialt is an intrathecal non-opioid pain medication for severe chronic pain when other treatments have failed.
Key facts at a glance
- RxNorm
- 497062
- Generic
- Prialt
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prialt is indicated for the management of severe chronic pain that requires intrathecal therapy and has not responded to other treatment modalities, including systemic analgesics and/or intrathecal morphine.
Prialt contains ziconotide, a synthetic peptide that blocks N-type calcium channels on neurons in the spinal cord. By inhibiting these channels, it prevents the transmission of pain signals from nerves to the brain, reducing the perception of pain.
Prialt must be administered by or under the direction of a healthcare professional experienced in intrathecal catheter management. Common side effects may include dizziness, confusion, and hallucinations. Patients require monitoring for signs of neurological or psychiatric adverse effects. This medication should not be discontinued abruptly without medical guidance.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy